Subclinical Chronic Lymphocytic Leukemia Associated with a 13Q Deletion Presenting Initially in the Skin: A Propos of a Case.
Identifieur interne : 008146 ( Main/Exploration ); précédent : 008145; suivant : 008147Subclinical Chronic Lymphocytic Leukemia Associated with a 13Q Deletion Presenting Initially in the Skin: A Propos of a Case.
Auteurs : K. Seilstad ; A. Khandelwal ; K. Gupta ; J. Byrd [États-Unis] ; C. MagroSource :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
Introduction: B‐cell chronic lymphocytic leukemia (B‐CLL) represents a low grade B cell lymphoproliferative disease with overlapping features with small lymphocytic lymphoma. The neoplastic cell is an autoreactive CD5 CD23 B lymphocyte. B‐CLL may involve the skin, typically in the context of known disease. We present a case of subclinical B‐CLL presenting initially in the skin. Results: A 73‐year‐old male developed a lesion on his right cheek in April 2003 compatible with basal cell carcinoma. The re‐excision specimen contained a well differentiated atypical lymphocytic infiltrate consistent with B‐CLL along with residual carcinoma. Subsequent laboratory studies revealed slight thrombocytopenia and mild peripheral blood lymphocytosis. A diagnosis was made of stage 0 CLL. Chromosomal studies on peripheral blood showed a deletion at 13q14.3. Conclusion: This case represents a cutaneous presentation of subclinical B‐CLL. There are two prior reports describing B‐CLL presenting initially in the skin. In one case the infiltrates were incidental on a re‐excision specimen. The second report suggests 16% of B‐CLL patients have cutaneous manifestations as the first sign of disease. Data indicates that 13q14 deletion in B‐CLL in early stage disease may portend a more aggressive course, possibly explaining its early presentation in the skin in our case.
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DOI: 10.1111/j.0303-6987.2005.320gr.x
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Seilstad</name><affiliation><wicri:noCountry code="no comma">Department of Pathology and the Department of Internal Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Khandelwal, A" sort="Khandelwal, A" uniqKey="Khandelwal A" first="A" last="Khandelwal">A. Khandelwal</name><affiliation><wicri:noCountry code="no comma">Department of Pathology and the Department of Internal Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Gupta, K" sort="Gupta, K" uniqKey="Gupta K" first="K" last="Gupta">K. Gupta</name><affiliation><wicri:noCountry code="no comma">Department of Pathology and the Department of Internal Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Byrd, J" sort="Byrd, J" uniqKey="Byrd J" first="J" last="Byrd">J. Byrd</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Ohio State University, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Magro, C" sort="Magro, C" uniqKey="Magro C" first="C" last="Magro">C. Magro</name><affiliation><wicri:noCountry code="no comma">Department of Pathology and the Department of Internal Medicine</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="115">115</biblScope><biblScope unit="page" to="115">115</biblScope><biblScope unit="page-count">1</biblScope><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01">2005-01</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Introduction: B‐cell chronic lymphocytic leukemia (B‐CLL) represents a low grade B cell lymphoproliferative disease with overlapping features with small lymphocytic lymphoma. The neoplastic cell is an autoreactive CD5 CD23 B lymphocyte. B‐CLL may involve the skin, typically in the context of known disease. We present a case of subclinical B‐CLL presenting initially in the skin. Results: A 73‐year‐old male developed a lesion on his right cheek in April 2003 compatible with basal cell carcinoma. The re‐excision specimen contained a well differentiated atypical lymphocytic infiltrate consistent with B‐CLL along with residual carcinoma. Subsequent laboratory studies revealed slight thrombocytopenia and mild peripheral blood lymphocytosis. A diagnosis was made of stage 0 CLL. Chromosomal studies on peripheral blood showed a deletion at 13q14.3. Conclusion: This case represents a cutaneous presentation of subclinical B‐CLL. There are two prior reports describing B‐CLL presenting initially in the skin. In one case the infiltrates were incidental on a re‐excision specimen. The second report suggests 16% of B‐CLL patients have cutaneous manifestations as the first sign of disease. Data indicates that 13q14 deletion in B‐CLL in early stage disease may portend a more aggressive course, possibly explaining its early presentation in the skin in our case.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><noCountry><name sortKey="Gupta, K" sort="Gupta, K" uniqKey="Gupta K" first="K" last="Gupta">K. Gupta</name><name sortKey="Khandelwal, A" sort="Khandelwal, A" uniqKey="Khandelwal A" first="A" last="Khandelwal">A. Khandelwal</name><name sortKey="Magro, C" sort="Magro, C" uniqKey="Magro C" first="C" last="Magro">C. Magro</name><name sortKey="Seilstad, K" sort="Seilstad, K" uniqKey="Seilstad K" first="K" last="Seilstad">K. Seilstad</name></noCountry><country name="États-Unis"><region name="Ohio"><name sortKey="Byrd, J" sort="Byrd, J" uniqKey="Byrd J" first="J" last="Byrd">J. Byrd</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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